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44 Furthermore, anergic cells Typically retain a better susceptibility to apoptosis Unless of course anti-apoptotic proteins including BCL2 are overexpressed, as is the case for CLL cells.45 Without a doubt, most big therapeutic developments taking place in the last decade are connected to the inhibition of BCR and BCL2-mediated signaling.
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translocations or amplifications on top of the genomic alterations previously present in the initial CLL, but deficiency the widespread mutations noticed in Major DLBCL indicating which they may possibly correspond to a different biological group.